加速度计的体力活动与肝纤维化相反相关;纵向队列的横截面分析
Madeleine G Haff1, Joanne M Murabito2,3, Ramachandran S Vasan2,3,4
1Section of Gastroenterology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
概括
定期体育活动,特别是中度至强度体育活动 (MVPA),与成人肝纤维化几率降低有关. 每周达到150分钟的MVPA显示出与较低纤维化风险的最强相关性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 运动生理学 运动生理学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 可以进展到晚期肝纤维化,增加死亡风险.
- 身体活动在管理MASLD相关纤维化的作用需要进一步描述.
研究的目的:
- 调查加速仪测量体力活动 (PA) 与肝纤维化之间的横截面关联.
- 为了确定中度至强度的体力活动 (MVPA) 是否与肝纤维化减少有关,独立于BMI和肥胖症.
主要方法:
- 利用振动控制的短暂弹性图谱测量2201名成年人的肝硬和纤维化.
- 使用加速度计数据量化每日和每周的体力活动水平.
- 进行了多变量回归分析,对年龄,性别,BMI和酒精消耗等关键共变量进行调整.
主要成果:
- 观察到MVPA和肝纤维化之间存在显著的反向关联.
- 每增加每天30分钟的MVPA都会降低纤维化几率 (或0.57),即使在调整了BMI或脂肪酸.
- 每周接受150分钟MVPA的个体患肝纤维化的几率最低 (或0.51).
结论:
- 在以社区为基础的队列中,花费在中度至剧烈体力活动中的时间增加与肝纤维化相反相关.
- 身体活动可能在缓解MASLD肝纤维化进展方面发挥关键作用.
- 需要进一步的干预研究来探索MVPA在逆转肝纤维化的潜力.
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