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免疫包装的T细胞-融合性脂质体增强了固体瘤治疗的采用T细胞疗法

Chunxiong Zheng^1,2, Ke Yi¹, Yongkang Du²

¹Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.

Advanced materials (Deerfield Beach, Fla.)

|October 7, 2025

概括

一个新的脂质体系统通过改善瘤透和克服免疫抑制来增强固体瘤的采用性T细胞治疗. 这种策略使T细胞能够向瘤,逆转微环境,并阻断免疫检查点,显著增强抗瘤活性.

科学领域:

免疫学免疫学免疫学
生物技术是生物技术.
纳米医学是一种纳米医学.

背景情况:

采用T细胞疗法对血液癌症有希望,但在固体瘤中面临挑战,包括透不良和免疫逃避.
瘤微环境 (TME) 通常会抑制抗瘤免疫反应,从而限制治疗疗效.

研究的目的:

开发一个单阶段的细胞工程策略,以加强对固体瘤的T细胞治疗.
克服阻碍T细胞对固体瘤有效性的关键免疫障碍.

主要方法:

一个T细胞-fusogenic脂质体,IMPACTFUL,被设计为同时装饰T细胞与DPA和交付interleukin-12mRNA载磁纳米粒子 (MNP/IL-12).
IMPACTFUL促进T细胞表面功能化和MNP/IL-12的细胞质输送,以增强瘤向和TME调节.
工程T细胞在小鼠实体瘤模型中进行了评估.

主要成果:

在IMPACTFUL工程T细胞在小鼠固体瘤模型中表现出增强的瘤透和耐耗性.
工程T细胞的IL-12表达促进了促炎性TME,而DPA阻断了PD-L1检查点.
与对照组相比,在接受IMPACTFUL工程T细胞治疗的小鼠中观察到显著的瘤生长抑制.

结论:

IMPACTFUL提供了一个多功能,单步平台,为T细胞提供多种抗瘤功能,解决固体瘤治疗的局限性.
这种方法显著改善了针对固体瘤的T细胞治疗结果,并具有临床转化潜力.

关键词:

收养的T细胞疗法细胞工程细胞工程融合性的脂质体组组合体.多个功能,多个功能.固体瘤是一个固体瘤.

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Tumor Immunotherapy

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