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Updated: Jan 15, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination

Published on: January 2, 2026

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通过VHL蛋白的APP无化对于MVB分类和溶酶体降解至关重要

Chunyan Shan1, Rixu Cong1, Xiangyu Xu1

  • 1Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.

Journal of molecular cell biology
|October 7, 2025
PubMed
概括

·希佩尔-林道蛋白 (VHL) 针对粉样蛋白前体蛋白 (APP) 进行降解,减少阿尔茨海默病 (AD) 病理. 在AD小鼠中,VHL的丧失加速了Aβ斑块沉积和记忆缺陷.

关键词:
MVB分类的排序方法粉样蛋白前体蛋白质是粉样蛋白的前体.lysosomal 降解 溶酶体降解 溶酶体降解无处不在的化希佩尔 林道蛋白质

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