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在阿尔茨海默病中使用扩散MRI衍生的自由水分数来识别柔性皮层微结构的明显时空模式

Junfang Zhang^1,2, Xinyuan Yang¹, Yan Wang³

¹Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd, Shanghai 200025, China.

|October 7, 2025

概括

自由水分 (FWF) 在阿尔茨海默氏症 (AD) 中升高,并与粉样β和病理有关. 独特的FWF进展模式与特定的认知缺陷相关,为AD提供潜在的成像见解.

科学领域:

神经成像是一种神经成像.
阿尔茨海默氏症疾病研究研究
生物标志物发现发现

背景情况:

自由水分 (FWF) 是阿尔茨海默病 (AD) 的新兴成像生物标志物.
了解FWF在AD进展中的作用及其与核心神经病理的关联至关重要.

研究的目的:

在患有AD和正常认知的个体中研究皮层旁FWF.
评估FWF,神经病理严重程度 (粉样β和tau) 和神经退行症之间的关系.
用先进的MRI和PET成像来描述FWF变化的时空模式.

主要方法:

一项前性研究分析了359名参与者对FWF的扩散MRI,18F-florbetapir PET对粉样β (Aβ) 的分析,18F-MK-6240 PET对tau的分析.
采用了两个亚型和阶段推断 (SuStaIn) 模型:一个分析FWF变化,另一个整合FWF和Aβ.
统计分析包括FDR校正来评估FWF,Aβ,tau和认知表现之间的关联.

主要成果:

与对照组相比,患有AD的参与者表现出显著增加的皮层下FWF (FDR校正P < .001到P = .049).
升高的FWF与较高的全球皮层Aβ和tau沉积相关 (FDR校正的P < .001到P = .04为Aβ;P < .001到P = .01为tau).
确定了两种不同的FWF时空轨迹:"轨道前前"亚型与较小的海马体积和较差的认知有关,以及与较高的粉样蛋白水平和减少皮质厚度相关的"粉样蛋白优先"亚型.

结论:

副皮层FWF在AD中升高,并与关键的AD病理 (Aβ,tau) 和神经退行症标志物有关.
FWF的独特的时空进展模式与差异性的认知性能配置文件有关.
FWF代表了一种有前途的成像生物标志物,用于表征AD亚型和进展.

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