微生物真核生物文学的一半只关注了12种人类寄生虫
Joanna A Lepper1, H Beryl Rappaport1, Angela M Oliverio1
1Department of Biology, Syracuse University, Syracuse, NY 13210, United States.
The ISME journal
|October 7, 2025
概括
对微生物真核生物的研究严重倾向于少数寄生虫物种,忽视了自由生活的原生体的巨大多样性. 这种偏见限制了我们对真核生物生命的理解.
科学领域:
- 微生物学 微生物学
- 单核细胞多样性 单核细胞多样性
- 生物信息学是一种生物信息学.
背景情况:
- 微生物真核生物体代表了大部分真核生物体的遗传学多样性.
- 大多数研究都集中在少数人类寄生虫物种上,忽视了全球微生物多样性.
- 原生体核糖体参考 (PR2) 数据库包含各种微生物真核细胞数据.
研究的目的:
- 量化已知微生物真核生物物种的研究范围.
- 为了确定微生物真核生物研究中的研究偏见.
- 突出研究不足但重要的微生物真核细胞系.
主要方法:
- 分析PubMed. 的出版数据.
- 文献挖掘专注于PR2数据库中的物种.
- 研究重点的定量评估跨微生物真核细胞.
主要成果:
- 几乎一半的出版物仅引用了10种原生动物物种.
- 12种人类寄生虫物种占文献的47%.
- 在研究中,自由生活的水生原生动物的代表性显著不足.
结论:
- 目前对微生物真核生物的研究重点高度偏见.
- 这种偏见限制了对真核细胞生物学的基本理解.
- 需要对代表性不足,生态意义重大血统进行进一步的研究.
相关概念视频
Fungal Phylum Microsporidia
422
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
422
Diversity of Protists I
850
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
850
Bacterial Phylum Chlamydiae
424
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
424
Diversity of Protists II
781
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
781
Overview of Protists
1.4K
Protists are diverse eukaryotic microorganisms that lack the specialized tissues of plants and animals and the chitinous cell walls of fungi. Their early divergence within Eukarya resulted in structural, functional, and ecological diversity. They are classified into supergroups such as Archaeplastida, Excavata, Amoebozoa, Rhizaria, Alveolata, and Stramenopiles, determined through genetic analysis and structural similarities.Structural and Functional AdaptationsProtists have various adaptations...
1.4K
Types of Microorganisms
1.7K
Microorganisms are a diverse group of microscopic entities broadly categorized into cellular and acellular types based on their structural organization. Cellular microorganisms include bacteria, archaea, fungi, protozoa, and algae, while acellular microorganisms are represented by viruses.Cellular MicroorganismsBacteriaBacteria, tiny prokaryotic organisms, exhibit fascinating shapes such as rods, spheres, and spirals. They adapt to diverse habitats, including soil, water, and human-associated...
1.7K


