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在上道泌尿道癌 (UTUC) 中缺陷的DNA不匹配修复和Nectin-4表达

Peichen Duan¹, Le Yu¹, Yichang Hao¹

¹Department of Urology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

Journal of cancer research and clinical oncology

|October 7, 2025

概括

缺陷的DNA不匹配修复 (dMMR) 在7.4%的上道泌尿道癌 (UTUC) 病例中被发现. 这种dMMR状态与升的Nectin-4表达有显著的相关性,这表明它是治疗策略的潜在生物标志物.

科学领域:

尿癌研究尿癌研究
癌症生物标志物癌症生物标志物
免疫组织化学免疫组织化学

背景情况:

上道泌尿道癌 (UTUC) 是一种罕见的恶性瘤.
了解像缺陷DNA不匹配修复 (dMMR) 这样的分子亚型对于向治疗至关重要.
尼克-4是尿路癌的新兴生物标志物.

研究的目的:

为了确定dMMR状态在UTUC的流行率.
调查dMMR和临床病理特征之间的关联.
探索dMMR和UTUC中的Nectin-4表达之间的关系.

主要方法:

对339个经组织学确认的UTUC病例进行了回顾性分析.
免疫组织化学被用来评估MMR蛋白表达 (dMMR与熟练的不匹配修复).
使用H分数系统量化和分类nectin-4表达.

主要成果:

7.4%的UTUC患者表现出dMMR状态.
在dMMR和升高的Nectin-4表达 (P=0.044) 之间发现了显著的关联.
在dMMR和pMMR组之间没有观察到临床参数的显著差异.

结论:

dMMR发生在7.4%的UTUC中,具有多样化的Nectin-4表达.
在dMMR和高Nectin-4表达之间存在显著的相关性.
这种结合的生物标志物概况可以预测对抗体-药物合物和免疫检查点抑制剂的反应.

关键词:

缺陷的DNA不匹配修复缺陷的DNA不匹配修复尼克-4的使用方法上部通道泌尿器癌癌.

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