便calprotectin可以指导怀疑有多的儿童需要结肠镜检查吗?
Anita Kolobarić1, Ivana Trivić Mažuranić2, Paola Ruška2
1Pediatric Department, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
European journal of pediatrics
|October 7, 2025
概括
便calprotectin (FCP) 是一种非侵入性生物标志物,可用于查儿童的结直肠多,从而减少结直肠镜检查的必要性. 增加的FCP水平与儿童的息肉有显著的关联.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 生物标志物发现发现
- 结肠直肠健康 结肠直肠健康
背景情况:
- 结肠直肠多是儿童下部胃肠道出血的重要原因.
- 目前,缺乏可靠的非侵入性生物标志物来识别需要结肠镜检查的儿科患者.
研究的目的:
- 评估便calprotectin (FCP) 作为潜在的查生物标志物,用于儿童的结直肠多.
- 为了确定FCP的诊断准确性,用于识别患有多发症的儿科患者.
主要方法:
- 一项回顾性,单中心的观察性研究,对672名接受结肠镜检查的儿童进行了观察.
- 在患有息肉的儿童和结肠镜检查结果正常的儿童之间比较FCP水平.
- 接收器操作特征 (ROC) 曲线分析以评估诊断性能和最佳切断值.
主要成果:
- 与对照组 (253.5 ± 544 μg/g) 相比,便中calprotectin水平在患有多的儿童中显著更高 (719.2 ± 1065 μg/g).
- ROC分析显示曲线下的面积 (AUC) 为0.727.
- 20.5μg/g的切断值实现了90%的灵敏度,741μg/g实现了90%的特异性来检测多重体.
结论:
- 便calprotectin可以作为一种有用的查工具,用于识别患结肠多风险的儿童.
- 进一步的前性研究和标准化的儿科切断是必要的,以验证其临床实用性,由于非特异性.
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