非典型大腿骨骨折的流行病学,病理生理学和管理:最新情况
Lucy Collins1,2,3, Hanh H Nguyen1,2,3,4, Frances Milat1,2,5
1Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Current osteoporosis reports
|October 7, 2025
概括
非典型的股骨骨折 (AFFs) 是抗吸收药物的罕见副作用,随着治疗持续时间的增加,风险会增加. 停药后风险降低,亚裔是关键因素. 治疗包括停止治疗和手术干预.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 非典型的股骨骨折 (AFFs) 越来越多地被认为是并发症.
- 它们与抗吸收药物,特别是双酸盐的相关性已经确立.
- 然而,AFFs也发生在双酸盐先天的个体和那些遗传骨疾病的人身上.
研究的目的:
- 审查最近关于非典型股骨骨折 (AFFs) 流行病学,病变发生和管理的文献.
- 突出新出现的风险因素和诊断方面的进展.
主要方法:
- 对近期出版物的系统审查.
- 对流行病学数据,致病机制和临床管理策略的分析.
主要成果:
- AFF的风险与抗吸收治疗持续时间的延长相关,但在停止治疗后会减少.
- 亚洲族裔是一个重要的风险因素.
- 周围假肢和非经典部位骨折越来越多地被报告.
- 治疗包括停止服用抗吸收药物,考虑手术固定 (骨髓内钉),逆侧大腿部成像和治疗骨质疏松症.
- 特里巴拉提德可能有助于手术治疗的AFF的愈合.
结论:
- AFF是罕见的,但与抗吸收疗法相关的重要不良事件.
- 对遗传/种族因素的进一步研究和改进的诊断是有必要的.
- 最佳的管理需要一个多学科的方法.
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