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Updated: Jan 15, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
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类风湿性关节炎的突纤维细胞调节T细胞激活

Melissa R Romoff1, Preethi K Periyakoil2, Edward F DiCarlo3

  • 1Research Institute, Hospital for Special Surgery, New York, New York, USA.

JCI insight
|October 7, 2025
PubMed
概括

在类风湿性关节炎 (RA) 中,纤维细胞样同胞细胞 (FLS) 通过IDO1-介导的托耗尽来抑制T细胞活化. 这突显了FLS作为RA突中的关键调节剂,表明治疗策略应该保留其免疫抑制功能.

关键词:
这是一种自身免疫力.免疫学 免疫学 免疫学类风湿病学 类风湿病学

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