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Updated: Jan 15, 2026

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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一个Orc6 tether在复制起源许可期间调解ORC绑定站点切换.

David Driscoll1,2, Larry J Friedman2,3, Jeff Gelles3

  • 1HHMI, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|October 7, 2025
PubMed
概括

原始识别复合体 (ORC) 使用Orc6在DNA复制启动过程中绑定Mcm2-7螺旋酶. 这种相互作用确保一个ORC有效地加载两个酶,防止其释放,并使细胞分裂成为可能.

关键词:
启动DNA复制的开始麦克米2 - 7直化酶原产地许可证的原产地许可证.原产地识别复合体 (ORC) 是一个复合体.单分子FRETET是一种单分子FRET.

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