在急性缺血性中风和短暂缺血性发作患者的口腔微生物组失生症
Duangnapa Roongpiboonsopit1, Sirikanya Wairit2, Chichaya Nithisathienchai1
1Division of Neurology, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
PloS one
|October 7, 2025
概括
口腔微生物组的变化,包括多样性增加和特定的细菌变化,与急性缺血性中风 (AIS) 和短暂缺血性攻击 (TIA) 有关. 唾液微生物组分析可以作为中风风险的非侵入性生物标志物,并了解其在炎症中的作用.
科学领域:
- 微生物组研究的研究.
- 口腔健康 口腔健康
- 神经学 神经学
- 血管健康 血管健康
背景情况:
- 口腔微生物群,一个复杂的细菌群体,在全身炎症和血管健康中发挥作用.
- 这些因素在缺血性中风的发病过程中至关重要.
- 了解口腔微生物群对中风的影响对于制定预防和治疗策略至关重要.
研究的目的:
- 为了研究急性缺血性中风 (AIS) 和过渡性缺血性发作 (TIA) 患者和匹配的健康对照之间的唾液微生物群的差异.
- 为了测试AIS和TIA患者表现出改变的口腔微生物组合的假设.
- 为了确定与中风病理生理学相关的特定微生物变化.
主要方法:
- 一项前性病例控制研究,涉及41名中风患者 (31名AIS,10名TIA) 和来自泰国的20名健康对照.
- 使用元基因组学和16S rRNA基因测序分析了唾液样本.
- 分析包括微生物的α多样性,分类构成,β多样性和功能途径.
主要成果:
- 与对照组相比,中风患者的α-多样性 (种类丰富性,OTUs,Chao1指数) 显著更高 (p < 0.001).
- 在患者中观察到Bacillota (p = 0.0285) 和Streptococcus (p = 0.0171) 的丰度增加,而Bacteroidota,Actinomycetota和Pseudomonadota的趋势下降.
- 贝塔多样性分析显示,患者和对照组之间存在明显的分离 (PERMANOVA,p < 0.001).
- 与异生菌生物降解,新陈代谢,心血管疾病,信号转导和膜传输相关的功能性途径在患者中明显高.
结论:
- 这项研究表明,AIS和TIA患者的唾液微生物组发生了显著的变化,其特点是增加多样性和明显的微生物变化.
- 这些微生物变化可能与中风相关的炎症有关,并有助于中风病理生理学.
- 唾液微生物组分析具有作为评估中风风险和理解其潜在机制的非侵入性生物标志物的潜力.
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