日本人肠道微生物组与大脑体积之间的关系 男人 男人
Sabrina Ahmed1,2, Zhang Hexun3, Yuichiro Yano1,4
1NCD Epidemiology Research Center (NERC), Shiga University of Medical Science, Otsu, Shiga, Japan.
PloS one
|October 7, 2025
概括
肠道微生物群的多样性与健康的日本老年男性的大脑体积有关. 特定的细菌,如Lachnospiraceae,与较高的白质体积有关,而其他细菌则与灰质体积有关.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 新兴证据表明肠-大脑轴,将肠道微生物组合与大脑健康联系起来.
- 之前的研究集中在动物模型或特定的患者群体上,使得健康人类的相关性未得到充分研究.
- 肠道微生物对看似健康的中年至老年人大脑体积的影响需要进一步调查.
研究的目的:
- 为了研究肠道微生物群多样性与大脑体积 (灰白质) 之间的联系,在一个看似健康的日本男性的基于人口的队列中.
- 为了确定与大脑体积变化相关的特定肠道微生物种群.
- 在老化过程中大脑结构变化的背景下探索肠-大脑轴.
主要方法:
- 623名日本男性的横截面研究来自西加亚临床动脉样硬化 (SESSA) 流行病学研究.
- 便样本的16S核糖体RNA基因测序以分析肠道微生物组合和多样性 (α和β多样性).
- 大脑磁共振成像与基于voxel的自动形态测量来量化灰色和白质量;统计分析包括主要坐标分析,线性判别分析和多变量线性回归.
主要成果:
- 在调整年龄和内体积后,灰质体积与肠道微生物群α多样性 (香农指数) 呈现出正相关性,但在进一步调整后,这并不显著.
- 贝塔多样性分析 (加权的UniFrac距离) 显示了大脑体积的明显聚类,表明与灰色和白色物质体积相关的微生物组合的差异.
- 几种细菌属与大脑体积有显著的关联; 拉克诺斯皮拉属 (黄酸盐生产者) 始终与较高的白质体积有关,而埃加特拉属,比菲多细菌属和塞勒诺蒙纳属与较高的灰质体积有关.
结论:
- 这项研究支持肠道微生物群多样性与中年至老年日本男性的大脑体积之间的关联.
- 特定的肠道细菌,如Lachnospiraceae,可能在维持白质体积方面发挥作用.
- 这些发现提供了对肠道微生物组对人类大脑结构和体积的潜在影响的见解.
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