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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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在人类肠道微生物群中,自诱因-2-介导的通信网络.

Qingying Fan1, Hengxi Sun2, Xueyuan Lin1

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人体肠道微生物使用定数感应 (QS) 进行通信,自动诱导器-2 (AI-2) 是最常见的信号. 这项研究揭示了AI-2

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人工智能-2受体 AI-2受体议员数量检测是指对议员数量进行检测.自动诱导器-2 自动诱导器-2通信网络 通信网络 通信网络 通信网络人的肠道微生物群

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科学领域:

  • 微生物学 微生物学
  • 微生物生态学 微生物生态学
  • 系统生物学 系统生物学

背景情况:

  • 定数感应 (QS) 是一种关键的细菌通信过程.
  • 质量系统调节肠道微生态,宿主营养和新陈代谢.
  • 了解人类肠道微生物群中的QS是有限的.

研究的目的:

  • 研究QS系统在人类肠道微生物群中的流行程度和多样性.
  • 在肠道微生物中识别主要的QS信号及其相关基因.
  • 探索由QS信号介导的功能角色和通信模式.

主要方法:

  • 从统一的人类胃肠道基因组集合中分析了289,232个 prokaryotic 基因组.
  • 识别和表征QS信号合成酶和受体基因.
  • 转录基因分析用于评估人类肠道中的基因表达.
  • 通信网络分析.

主要成果:

  • 自动诱导剂-2 (AI-2) 是最普遍的QS信号,在2039个物种中发现了luxS合成酶基因.
  • 299种物种拥有AI-2受体的基因 (LuxP-, LsrB-, dCache_1-, GAPES1-类型).
  • AI-2受体表现出多种功能,包括化学反应和信号传递中的作用.
  • 通过AI-2介导的相互作用在主要肠道菌群 (Firmicutes,Proteobacteria,Actinobacteriota等) 中广泛存在. ) 的情况.

结论:

  • AI-2是人类肠道微生物群中占主导地位的QS信号.
  • 有多种AI-2介导的物种间通信通道存在.
  • 在各种健康状况下,QS基因表达发生在人类肠道中.
  • 结果为工程肠道微生物群和合成联盟提供了洞察力.