微塑料对水生生物的生态毒性负面结果途径网络:批判性审查
Nik Nurhidayu Nik Mut1, Zhihan Cao1, Joorim Na2
1Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, , Republic of Korea.
Aquatic toxicology (Amsterdam, Netherlands)
|October 7, 2025
概括
微塑料在水生生物中的生态毒性是已知的,但机制尚不清楚. 本综述提出了微塑料发起事件的新定义,并绘制了了解水生生物有害性的途径.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 分子生物学分子生物学
背景情况:
- 水生生物中的微塑料生态毒性已被记录,但机械性途径仍然不太清楚.
- 现有的框架很难为微塑料等非化学压力因素定义分子启动事件.
研究的目的:
- 系统地识别微塑料毒性的分子启动事件 (MIE),关键事件 (KE) 和不良结果 (AO).
- 构建和评估水生生物中的微塑料暴露的假定不利结果途径 (AOP) 网络.
- 为颗粒物压力因素提出适应的MIE定义.
主要方法:
- 综合的多层次生态毒理学审查与自动化文本挖掘集成 (AOP-helpFinder 3.0).
- 确定压力因素-事件和事件-事件关系与信心评分.
- 构建基于敏感组织和使用布拉德福德山标准的评估的假定AOP网络.
主要成果:
- 构建了一个假定的AOP网络,在各种水生组织中识别候选MIE,KE和AO.
- 证据权重评估显示,早期和中游的KE关系得到了强烈支持,但下游链接的证据很弱.
- 建议最初的上皮相互作用是水生生物中微塑料毒性的MIE.
结论:
- AOP框架可以定性地组织微塑料毒性的机械证据.
- 拟议的AOP网络为预测性生态毒理学评估提供了一个结构化的基础.
- 这些发现支持制定水生生态系统中微塑料污染的监管策略.
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