加拿大意外药物过量死亡的趋势:1974年至2023年的分析
Harika Dasari1, Adelina Artenie2, Julie Bruneau3
1Department of Biomedical Sciences, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
The International journal on drug policy
|October 7, 2025
概括
加拿大加拿大加拿大加拿大加拿大加拿大
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 自2016年以来,加拿大的过量死亡人数一直在持续上升,但长期死亡趋势需要进一步描述.
- 了解历史过量模式对于制定有效的公共卫生干预措施至关重要.
- 以前的分析没有完全捕捉到加拿大过量死亡率的多十年趋势.
研究的目的:
- 检查1974年至2023年期间加拿大的全国过量死亡趋势.
- 调查过量死亡的人口变化,特别是按性别和年龄组.
- 分析加拿大各省过量使用死亡率的地理差异.
主要方法:
- 追溯分析意外和不确定的故意中毒死亡.
- 使用了加拿大生命统计局死亡数据库和加拿大统计局的人口估计.
- 雇佣细分回归分析以建模时间趋势并计算平均年均百分比变化 (AAPC),按性别,年龄 (<25,25-44,45-64,≥65) 和省份分层.
主要成果:
- 在1974年至2023年期间记录了80,944例过量死亡,显示了三个不同的阶段:稳定 (1974-1991),随后有两个显著的加速 (1991-2013和2013-2023).
- 过量服用死亡率最初在两性之间相似,在2013年至2015年后急剧上升,男性 (AAPC: 13.81%) 的加快率高于女性 (AAPC: 9.32%).
- 年龄特异性趋势显示,2014-2017年年轻人 (<25) 的急剧增长,而所有成年年龄组都经历了最近的增长,年龄≥65 (AAPC:18.48%) 的人群的加速速度最高. 西部省份呈现出最实质性的利率上.
结论:
- 加拿大的过量使用流行病遵循一个细分的轨迹,在1996年和2013年加速,受到医疗保健实践,药品市场和社会因素的影响.
- 显著的区域和人口差异需要制定有针对性的,历史性公共卫生战略.
- 调查结果强调了过量危机的不断变化的性质,以及需要基于证据的适应性干预措施.
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