在早产新生儿中,氨基酸和瘦肉量增加
Antonio C Ramos Dos Santos1, Marta L Fiorotto2, Teresa A Davis1,2
1Institute for Advancing Health Through Agriculture, Texas A&M AgriLife, Texas A&M University, College Station.
Current opinion in clinical nutrition and metabolic care
|October 7, 2025
概括
优化早产婴儿的营养是关键. 早期肠道养和脉动性营养物质输送等策略可以改善蛋白质合成和瘦肉量增长,克服食抵抗.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 生物化学 生物化学
背景情况:
- 过早出生的新生儿往往会经历合成代谢抵抗,其特点是骨肌肉中信号通路受损.
- 这种抵抗阻碍了它们有效利用营养素以促进生长和发育的能力.
研究的目的:
- 审查当前关于蛋白质和能量摄入,氨基酸概况和养方法如何影响早产婴儿蛋白质合成的证据.
- 为基于证据的营养策略提供信息,以增强瘦肉质的增加和这一脆弱人群的整体增长.
主要方法:
- 系统审查最近的科学文献.
- 对研究不同营养干预措施对早产新生儿蛋白质合成和生长标志物的影响进行分析.
主要成果:
- 肠道营养,特别是强化母乳,与肠道营养相比,在肌肉质量增加和神经发育方面表现出优异的结果.
- 间歇性玻尿酸食和脉冲性白补充剂可以提高mTORC1信号传递和骨肌肉中的蛋白质合成效率.
- 过早出生的婴儿表现出胰岛素和氨基酸信号受损,这有助于合成代谢抵抗.
结论:
- 优先考虑早期的肠道养和适当的牛奶强化对于早产婴儿的成长至关重要.
- 模仿自然养脉动性的营养物质输送模式可以帮助克服合成代谢抵抗.
- 这些策略支持更健康的生长轨迹和早产婴儿的最佳瘦身量发展.
更多相关视频
相关概念视频
Proteins: Dietary Sources and Requirements
1.5K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.5K
Overview of Protein Metabolism
3.6K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
3.6K
Mass Spectrometry of Amines
5.3K
In mass spectroscopy, amines undergo fragmentation to give parent ions with odd molecule weights. This observed mass spectrum follows the nitrogen rule; a molecule with an odd number of nitrogen atoms produces a molecular ion with an odd molecular weight. Amines undergo fragmentation through α cleavage, producing nitrogen-containing cations—iminium ions—and alkyl radicals. Mass spectra of aromatic and cyclic aliphatic amines exhibit strong molecular ion peaks, but acyclic...
5.3K
Amino Acid Biosynthetic Pathways
1.1K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.1K
Pharmacokinetics in Pediatric Patients: Drug Distribution
252
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
252
Protein Absorption
916
Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
916


