孤立REM睡眠行为障碍患者的主观认知能力下降
Anja Ophey1,2, Sinah Röttgen3,4, Christopher E J Doppler3,4
1Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. anja.ophey@uk-koeln.de.
NPJ Parkinson's disease
|October 7, 2025
概括
在孤立的REM睡眠行为障碍 (iRBD) 中,主观认知衰退 (SCD) 是常见的,并与微妙的认知问题和大脑变化有关. 需要进一步的研究来了解其长期影响.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 主观认知衰退 (SCD) 可能是轻度认知障碍 (MCI) 的前身.
- 孤立REM睡眠行为障碍 (iRBD) 是神经退行性疾病的潜在前兆阶段.
- 在iRBD中了解SCD对于早期检测和干预至关重要.
研究的目的:
- 调查iRBD患者中SCD的患病率和特征.
- 为了比较iRBD个体与没有SCD之间的认知表现和大脑结构.
- 探索SCD严重程度,认知缺陷和神经成像发现之间的关联.
主要方法:
- 对80名患有iRBD的个体进行横截面研究.
- 将其分类为有MCI的iRBD (RBD.MCI),有SCD的 (RBD.SCD+) 和没有两者的 (RBD.SCD-).
- 神经心理学测试,多次CoDE问卷和磁共振成像 (MRI).
主要成果:
- 在iRBD中,SCD的患病率为36.3%,主要是多领域的amnestic.
- 与RBD.SCD-.SCD相比,RBD.SCD+组表现出更严重的抑郁症状和较低的认知表现 (全球,注意力,工作记忆).
- 在RBD.SCD+与RBD.SCD-相比,在左上额头环中观察到较低的灰质体积,与SCD严重程度和全球认知相关.
结论:
- 即使没有MCI,iRBD中的SCD也与微妙的认知缺陷有关.
- 额叶中的结构性大脑变化与iRBD中的SCD严重程度有关.
- 长度研究是必要的,以确定SCD在iRBD的预后价值.
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