过敏和癌症之间的相关性:系统性审查和元分析
Shushu Guo1,2, Xiaoyu Fan2, Wanfang Li2,3
1Department of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Scientific reports
|October 7, 2025
概括
过敏可能会预防一些癌症,如结肠直肠癌和脑癌,但 atopic 过敏可能会增加淋巴瘤的风险. 证据质量低,需要谨慎解释和进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 对过敏和癌症风险之间的联系进行了辩论.
- 以前的研究表明,有关过敏对癌症发病率的影响的结果是相互矛盾的.
研究的目的:
- 系统地审查和对过敏和癌症之间的关联进行meta-analyze研究.
- 评估不同类型的过敏对各种癌症发病率的影响.
主要方法:
- 53个病例控制和队列研究的系统审查和元分析.
- 专注于癌症发病率,并计算了95%置信区间 (CI) 的聚合几率比率 (OR).
- 使用GRADE框架评估证据的确定性.
主要成果:
- 过敏与结直肠癌 (OR 0.77),胰腺癌 (OR 0.68) 和脑癌 (OR 0.66) 有显著的反向关联.
- 喘与淋巴瘤 (OR 0.81) 和妇科癌症 (OR 0.72) 的风险降低有关.
- 亚托皮性过敏与淋巴瘤风险增加有关 (OR 2.02),而肺癌,白血病和胃肠道癌症的证据确定性非常低.
结论:
- 过敏可能会对某些癌症产生保护作用,但亚托皮性过敏可能会增加其他癌症的风险.
- 过敏和癌症之间的关系是复杂和异质的.
- 由于证据的确定性低至非常低,需要进一步进行高质量的研究.
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