与 Porphyromonas gingivalis 感染相关的牙周炎是通过子宫缩导致不孕症的危险因素
Chiaki Kamei-Nagata1, Kazuhiro Omori2, Hidefumi Sako3
1Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8525, Japan.
Scientific reports
|October 7, 2025
概括
牙周炎是一种口腔炎症,与不孕症有关. 这项研究发现,不孕妇女对某些细菌的抗体水平较高,小鼠的牙周炎会影响怀孕结果,并改变子宫功能.
科学领域:
- 生殖免疫学 生殖免疫学
- 口腔微生物学 口腔微生物学
- 牙周病学 牙周病学
背景情况:
- 牙周炎越来越被认为是不孕不育的潜在危险因素.
- 关联牙周炎症与受孕受损的精确机制在很大程度上是未知的.
- 这项研究探讨了牙周炎和不孕症之间的关联,重点关注免疫反应和子宫功能.
研究的目的:
- 为了研究血清IgG抗体标位对妇女有不明原因的不孕不育期病原菌.
- 用小鼠模型检查牙周炎症对怀孕和子宫功能的影响.
- 阐明牙周炎可能影响生殖成功的潜在机制.
主要方法:
- 在接受不孕症治疗的妇女和自发怀孕的妇女中,用ELISA测量了针对七种周期性病原菌的血清IgG抗体标位.
- 一个被 Porphyromonas gingivalis (Pg) 感染的绑定诱导牙周炎小鼠模型被用于评估怀孕结果.
- 用组织学和免疫组织化学分析子宫组织,以检测炎症和激素受体表达.
主要成果:
- 接受不孕治疗的妇女与自发怀孕的妇女相比,对特定的Pg菌株的IgG标位显著更高.
- 小鼠的牙周炎导致出生数量减少,新生儿体重降低,子宫横截面积增加.
- 在患有牙周炎的小鼠的子宫组织中观察到雌激素受体α和孕受体表达的升高.
结论:
- 牙周炎可能通过针对牙周病原性细菌的免疫反应导致不孕.
- 牙周炎症可能会对怀孕结果产生负面影响,并改变子宫形态和激素受体表达.
- 这些发现表明牙周炎引起的子宫变化,包括缩和改变的激素信号,可能会损害成功的受孕和妊娠.
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