胰岛素补充剂调节与肥胖儿童大脑功能相关的肠道微生物群衍生代谢物
Tushar Andriyas1,2, Sira Sriswasdi3,4, Rossarin Tansawat1,2
1Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Scientific reports
|October 7, 2025
概括
在患有肥胖症的儿童中,胰岛素补充剂通过增加特定的氨基酸 (如普特雷辛) 来增强肠-大脑轴 (GBA) 通信. 这表明胰岛素可以通过调节GBA通路来帮助管理儿童肥胖症.
科学领域:
- 微生物组研究的研究.
- 代谢健康 代谢健康
- 肠-大脑轴 (GBA) 信号传递
背景情况:
- 肠道微生物群通过肠-大脑轴 (GBA) 影响能量平衡.
- 肠道失调与肥胖的发展有关.
- 了解GBA调节对于管理儿童肥胖至关重要.
研究的目的:
- 研究胰岛素补充剂对肥胖儿童中与GBA相关的氨基酸和生物活性分子的影响.
- 评估GBA化合物变化与肠道微生物群组成之间的关系.
- 通过GBA途径探索胰岛素在儿童肥胖管理中的潜在作用.
主要方法:
- 一项为期6个月的随机对照试验,涉及154名患有肥胖症的儿童 (7-15岁).
- 三组:胰岛素补充剂,马尔托德克斯特林安慰剂和食纤维建议.
- 使用LC-MS/MS分析血氨基酸和生物活性分子;评估肠道微生物群的变化.
主要成果:
- 与安慰剂相比,胰岛素补充剂导致普特雷辛,精氨酸和氨酸的显著增加.
- 在胰岛素组中,普素水平随着时间的推移而显著上调.
- 在胰岛素组中,与GBA相关的化合物的变化与肠道微生物群的变化有显著的相关性.
结论:
- 胰岛素有效调节与GBA相关的生物活性分子,包括普特雷辛,精氨酸和氨酸.
- 胰岛素补充剂可以增强GBA通信,为儿童肥胖管理提供潜在的策略.
- 用胰岛素准肠道微生物群,有望改善肥胖儿童的代谢健康.
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