阴道微生物组的变化,在女性患者的阴道菌和其对持续的HPV感染的影响
Zhiyu Liu1, Yinhua Wu2, Chen Wang2
1The First Affiliated Hospital, Zhejiang University School of Medicine, 79# Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Scientific reports
|October 7, 2025
概括
阴道微生物组的变化与状腺 (CA) 和持续的人类乳头瘤病毒 (HPV) 感染有关. 像P. bivia这样的特定细菌可能表明HPV持久,这表明阴道菌群.
科学领域:
- 妇科 妇科医生 妇科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 阴茎瘤 (CA) 是一种常见的性传播感染,由人类乳头瘤病毒 (HPV) 引起.
- 阴道微生物组在生殖健康和易受HPV感染方面发挥着至关重要的作用.
- 阴道微生物组在CA发展,HPV持久性和复发中的特定作用尚未完全理解.
研究的目的:
- 调查阴道CA.女性患者阴道微生物群的变化.
- 确定阴道失生症是否有助于持续的HPV感染和CA复发.
主要方法:
- 来自63名女性CA患者和20名健康对照的阴道拭子的16S rRNA基因测序.
- 将CA患者分为HPV持续阳性 (HPV_PP) 和HPV转阴性 (HPV_TN) 组的分层.
- 微生物组成,多样性和功能特征的分析,包括KEGG通路丰富.
主要成果:
- 阴道微生物群的组成和功能在CA患者和健康对照人群之间有所不同,CA的α多样性增加.
- 在CA患者中观察到P. bivia,G. asaccharolytica,S. agalactiae和M. hominis的升高水平.
- 在HPV_PP组中,P. bivia和A. prevotii更为丰富,与信号转导和药物耐药性相关的KEGG通路在这个组中得到了丰富.
结论:
- 变化的阴道菌群组成和功能与阴道CA相关.
- P. bivia可以作为持续性HPV感染的诊断生物标志物.
- 阴道失生症与CA复发和持续的HPV感染有显著的联系.
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