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在NMOSD AQP4+患者中,IL-1β有助于神经障碍

Antonio Bruno¹, Angela Borrelli¹, Gianluca Lauritano¹

¹IRCCS Neuromed, Via Atinense, 18, Pozzilli (IS), 86077, Italy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|October 7, 2025

概括

带有水素-4 (AQP4) 抗体的神经脊髓炎光谱障碍 (NMOSD) 患者在脑脊液 (CSF) 中表现出较高水平的某些炎症性细胞因子. 在NMOSD CSF中IL-1β升高与增加的神经障碍有关,这表明其作为生物标志物的潜力.

科学领域:

神经免疫学神经免疫学
中枢神经系统的炎症性疾病.
发现生物标志物的发现.

背景情况:

神经脊髓炎光谱障碍 (NMOSD) 是一种严重的中枢神经系统炎症状况.
一部分NMOSD患者具有水-4 (AQP4) 抗体.
细胞因子概况可能会影响NMOSD的发病,活性和严重程度.

研究的目的:

在AQP4阳性NMOSD患者中调查脑脊液 (CSF) 中的细胞因子水平.
评估CSF细胞因子与神经障碍之间的关系.
将这些发现与复发性复发性多发性硬化症 (RRMS) 和非炎症对照 (NIC) 进行比较.

主要方法:

招募了64名参与者,11名NMOSD AQP4+,29名RRMS,24名NIC.
使用多重测定测量了CSF细胞因子水平.
通过使用统计测试和回归模型,分析了群体差异和细胞因子障碍相关性.

主要成果:

与RRMS和NIC组相比,NMOSD AQP4+患者的IL-1β,TNF-α,G-CSF,Eotaxin和MIP-1α的CSF水平显著更高.
在椎穿刺时,CSF IL-1β水平与神经障碍正相关 (EDSS分数).
这种关联在调整年龄后仍然显著.

结论:

亲炎性细胞因子表达模式可以区分NMOSD和RRMS.
在NMOSD AQP4+患者中,CSF IL-1β升高与较大的神经障碍有关.
IL-1β可能作为NMOSD严重程度的生物标志物,需要进一步研究治疗向.

关键词:

亚波林-4是一种亚波林-4 细胞因子 (cytokines) 是一种细胞因子.障碍残疾是指残疾人的残疾.一个IL-1ββ.这是NMOSD的NMOSD.神经炎症是一种神经炎症.

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