高可膨胀的聚合物纳米材料的特性和安全性评估,以提高阿西克洛维尔的溶解性
Ayesha Umar1, Kashif Barkat2,3, Syed Faisal Badshah4
1Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Scientific reports
|October 7, 2025
概括
较差的水溶性限制了药物的有效性. 使用自由基聚合制成的纳米材料显著提高了阿西克洛维尔的溶解性和生物可用性,在毒性研究中证明了生物相容性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 治疗剂的有效性严重依赖于水溶性.
- 溶解不良的药物表现出受损的吸收和生物可用性.
- 提高药物溶解度对于最大限度地提高治疗结果至关重要.
研究的目的:
- 通过使用纳米来提高阿西克洛维尔的水溶性.
- 在结构上和体外 (in vitro) 描述所制备的纳米模块.
- 为了评估纳米矩阵系统的生物相容性.
主要方法:
- 纳米材料通过自由基聚合合成.
- 使用FTIR,SEM和PXRD进行结构性表征.
- 在体外研究包括sol-gel分量,胀,药物释放和可溶性评估.
- 通过对子的毒性研究来评估体内生物相容性.
主要成果:
- FTIR证实了在未加载和药物加载的纳米模块中存在功能组.
- SEM表明适合有效的药物加载,而PXRD显示出无形性质.
- 颗粒大小分析证实了纳米尺寸 (282.4 ± 09.43 nm).
- 纳米模块表现出pH响应的胀和药物释放,pH值在6.8时的释放量较高,而pH值在1.2时的释放量较高.
- 与纯药物相比,观察到阿西克洛维尔显著提高了溶解度.
- 毒性研究证实了该系统的生物相容性.
结论:
- 自由基聚合有效地产生了具有增强溶解性的含有乙烯基的纳米材料.
- 这些纳米模块表现出了依赖pH值的行为,并改善了药物释放.
- 配制的纳米基质是生物相容的,是改善阿西克洛维尔生物可用性的有希望的方法.
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