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对精神分裂症患者使用长效注射剂:共识小组建议克服障碍并实施治疗
John M Kane1,2,3, Ofer Agid4,5, David J Castle6,7
1Department of Psychiatry, Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY, USA. JKane2@northwell.edu.
Neurology and therapy
|October 7, 2025
概括
长效注射抗精神病药 (LAI) 可以改善精神分裂症治疗的坚持. 专家建议解决LAI启动和使用的障碍,促进常规实施以获得更好的患者结果.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 药理学和治疗学 药理学和治疗学
背景情况:
- 精神分裂症治疗的坚持是一个持续的挑战,影响复发率和患者的治疗结果.
- 长效注射抗精神病药 (LAI) 是一种潜在的解决方案,可以改善患者对口服药物的坚持.
- 现有的LAI使用障碍是医疗保健专业人员缺乏实用,专家驱动的建议.
研究的目的:
- 制定关键建议,以克服长效注射抗精神病药物 (LAI) 在精神分裂症中的使用障碍.
- 提供关于启动,监测和维护常规精神分裂症护理的LAI的指导.
- 建立专家对LAI实施最佳实践的共识.
主要方法:
- 采用了经过修改的Delphi小组方法,涉及12名具有不同经验的国际专家.
- 对过去10年内发表的英语文章进行了叙事文献审查.
- 专家小组成员参加了在线预会议和虚拟小组会议,以评价和完善拟议的陈述,达成≥75%的共识共识.
主要成果:
- 制定了26份共识声明,解决LAI启动和在精神分裂症中使用的障碍.
- 建议在确认精神分裂症诊断后主动考虑和早期启动LAI.
- 强调 LAI 在评估不坚持和治疗耐药性的重要性,并建议医疗保健人员通过教育和培训来解决个人偏见,以便共同决策.
结论:
- 专家共识提供了实用建议,以指导医疗保健专业人员克服LAI障碍.
- 这些建议促进了LAI作为精神分裂症标准治疗的实施,监测和维护.
- 本指南旨在改善LAI的常规使用,增强精神分裂症管理和患者的治疗结果.
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