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在血管疾病中自然存在的H₂S-捐赠体

Lorenzo Flori¹, Jacopo Spezzini¹, Eugenia Piragine^1,2

¹Department of Pharmacy, University of Pisa, Pisa, Italy.

Handbook of experimental pharmacology

|October 7, 2025

概括

硫化 (H2S) 对心血管健康至关重要,作为抗氧化剂和血管松剂. 来自植物的天然H2S捐赠者可以恢复H2S平衡,可能预防诸如高血压和动脉样硬化等心血管疾病.

科学领域:

心血管科学心血管科学
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

硫化 (H2S) 是一种内源性气递质,对心血管健康至关重要,具有抗氧化和血管松性质.
H2S影响涉及通道,Sirtuins,Nrf2,NF-κB和氧化 (NO) 的途径.
H2S恒温的失调与心血管疾病 (如高血压,动脉样硬化和糖尿病血管并发症) 有关.

研究的目的:

探索外源H2S捐赠者的治疗潜力,特别是天然化合物,用于治疗心血管疾病.
研究植物H2S供体在恢复H2S平衡中的作用及其对心血管健康的影响.

主要方法:

对H2S和自然H2S捐赠者的临床前和临床研究的审查.
分析像Alliaceae,Brassicaceae和Moringaceae这样的植物家族作为H2S捐赠化合物 (多硫化物,异硫酸) 的来源.
在临床前模型中评估植物提取物和分离化合物对心血管参数的影响.

主要成果:

临床前研究表明植物提取物和化合物 (多硫化物,ITC) 具有抗氧化,血管保护和抗高血压作用.
在研究中,大提取物表明降低了血压,内皮功能障碍和动脉样硬化.
临床研究证实了大对脂质样本的积极影响,但没有显示出对健康人群血压的显著影响. ITC的临床研究显示,脂质状况有所改善.

结论:

自然的H2S供体,包括植物衍生化合物,在恢复H2S平衡方面表现有前途.
这些天然化合物可能为预防和治疗心血管疾病提供治疗策略.
需要进一步的临床研究,以充分阐明自然H2S捐赠者的心血管益处.

关键词:

艾莉亚家族 (Alliaceae) 的一个家族.这种植物是Brassicaceae.硫化是一种硫化.异硫酸酸盐是什么异硫酸酸盐是什么自然的H2S捐赠者聚硫化物多硫化物血管疾病是血管疾病.

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