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Updated: Jan 15, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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在GPCR药物发现中偏差的体调制

Jingzhi-Christina Zhou1,2, Michelle Z Li2,3, Alan Long2,4

  • 1Department of Chemistry, Duke University, Durham, NC, USA.

Handbook of experimental pharmacology
|October 7, 2025
PubMed
概括

阿洛斯特基调制剂可以精确控制G蛋白合受体 (GPCRs) 信号传输,通过减少副作用来增强药物发现. 偏差基调制剂 (BAMs) 是开发向治疗的有希望的策略.

关键词:
艾洛斯特里克调制 (Allosteric) 是一种调制.药物发现 药物发现功能选择性的功能选择性.G蛋白结合受体 (GPCR) 是一种信号偏差是指信号偏差.治疗开发的治疗方法.

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