揭露隐藏的趋势:西班牙结肠直肠和门癌的分部特定死亡率模式,1999-2023年
Lucía Cayuela1, Victoria Achaval1, Gema Flox-Benítez1,2
1Department of Internal Medicine, Hospital Severo Ochoa, Leganés, Spain.
概括
在西班牙,结直肠癌的死亡率在结直肠和直肠子部下降,但在直肠结节的趋势停滞不前,在门癌的死亡率上升,特别是在女性中. 这凸显了需要特定于子站点的预防策略的需要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 涵盖了各种各样的亚部位,死亡率趋势各不相同.
- 了解长期死亡模式对于有针对性的公共卫生干预至关重要.
研究的目的:
- 分析西班牙四个结直肠癌分站点的长期死亡率趋势 (1999-2023年).
- 通过性别,年龄和出生队列来调查结肠,直腰结节,直肠和门癌的趋势.
主要方法:
- 使用西班牙国家死亡率数据 (ICD-10代码C18-C21) 的生态时间趋势研究.
- 使用2013年欧洲标准人口计算的年龄标准化率.
- 用于评估趋势和影响的joinpoint回归和年龄周期队列模型.
主要成果:
- 结肠癌的死亡率在女性中下降,在男性中呈现双相趋势. 在女性和最近在男性中,直肠癌死亡率持续下降.
- 乳结结癌的死亡率保持稳定. 癌死亡率在男性中增加,在女性中显著增加,缩小了性别差距.
- 死亡率随着年龄的增长而增加;男性的总体死亡率较高,除了年轻女性的门癌. 队列分析显示,结肠/直肠癌的几代人数下降,但门癌风险上升,与HPV有关.
结论:
- 结肠癌和直肠癌的死亡率有所下降,但直腰结节的停滞和门癌死亡率的上升需要特定亚部位的策略.
- 门癌症的增加趋势,特别是在女性中,表明需要针对HPV的预防干预措施.
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