相关实验视频
Updated: Jan 15, 2026

08:17
A Proximal Culture Method to Study Paracrine Signaling Between Cells
Published on: August 28, 2018
10.0K
外体介导的代谢重编程:对甲状腺癌进展和瘤微环境重塑的影响
Shouhua Li1, Hengtong Han2, Kaili Yang1
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Molecular cancer
|October 7, 2025
概括
甲状腺癌 (TC) 细胞通过瘤微环境 (TME) 中的外体重新编程新陈代谢. 本综述详细介绍了外体如何驱动TC的进展,为先进的放射性耐火性TC提供了新的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 代谢重编程是甲状腺癌 (TC) 的标志,涉及线粒体功能障碍,改变糖解,脂质代谢和谷氨酸依赖.
- 外体,细胞外囊泡,是TC瘤微环境 (TME) 中的关键媒介,运输蛋白质,脂质和核酸.
- 外体细胞促进TME内的瘤和非瘤细胞之间的双向通信,推动代谢重编程.
研究的目的:
- 通过代谢重编程系统地审查外体在促进甲状腺癌进展中的作用.
- 阐明外体对TC细胞特征和免疫微环境的影响机制.
- 确定局部先进的放射性耐火性TC的潜在诊断和治疗策略.
主要方法:
- 在甲状腺癌中调查外体功能和代谢重编程的研究的文献综述.
- 在TC瘤微环境中对外体介导的通信网络的分析.
- 对外体对TC细胞增殖,入侵,转移,血管新生,耐药性和免疫逃脱如何影响现有知识的综合.
主要成果:
- 在TC TME内分泌的外体显著改变癌细胞代谢,促进扩散,入侵和转移.
- 外体介导的代谢重编程有助于甲状腺癌的耐药性和免疫耐受性.
- 涉及外体的复杂调节网络塑造了免疫微环境,影响了免疫逃生.
结论:
- 外体是甲状腺癌进展的关键参与者,通过TME内的代谢重编程.
- 针对外体介导的代谢途径为新型诊断和治疗提供了有前途的途径.
- 了解外体体-TME相互作用对于管理先进的,耐放射性抗性甲状腺癌至关重要.
相关概念视频
Overview of Exosomes
3.5K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.5K
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Synthesis and Regulation of Thyroid Hormones
7.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.2K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K

