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Updated: May 11, 2026

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

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小分子介导的功能性人类星体细胞的快速生成:揭示了在星体细胞发育中的AKT1-STAT1/3信号

Pretty Garg1, Kerstin Lenk2,3, Sivaraj Mohana Sundaram4

  • 1Institute of Neuro- and Sensory Physiology, Heinrich Heine University, 40225, Duesseldorf, Germany. gpretty26@gmail.com.

Stem cell research & therapy
|October 7, 2025
PubMed
概括

一种新的小分子方法在2-3周内从神经干细胞迅速产生成熟的人类星体细胞. 这通过克服漫长的分化时间,加速了对神经系统疾病和药物查的研究.

关键词:
一个AKT1一个AKT1基原始体的原始体人类的iPSCs.抑制MEK的抑制方法成熟的人类星体细胞.神经干细胞的神经干细胞在OLIG2中,OLIG2是OLIG2的前身.小分子分子 小分子分子

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

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Culturing In Vivo-like Murine Astrocytes Using the Fast, Simple, and Inexpensive AWESAM Protocol07:56

Culturing In Vivo-like Murine Astrocytes Using the Fast, Simple, and Inexpensive AWESAM Protocol

Published on: January 10, 2018

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Mitogens and the Cell Cycle

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The JAK-STAT Signaling Pathway

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PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
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