对于老年人的认知,MIND饮食的效果修饰剂:MIND饮食试验
Shannon Halloway1, Neelum T Aggarwal2,3, Konstantinos Arfanakis2,4
1Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, Illinois, USA.
概括
地中海饮食方法对心性高血压干预神经退行性延迟 (MIND) 饮食改善了肥胖个体 (BMI ≥35 kg/m2) 的认知能力. 这突出了MIND饮食的重要意义.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 研究参与者特征作为地中海饮食方法对静脉压高压干预神经退行性延迟 (MIND) 饮食对认知的影响的潜在修饰者.
- 在分析中包括社会人口统计学,APOE ε4等位基因,生活方式和心血管风险因素.
研究的目的:
- 为了确定参与者的特征是否会改变MIND饮食的认知益处.
- 具体研究了MIND饮食与诸如身体质量指数 (BMI) 等因素对认知变化的相互作用.
主要方法:
- 在MIND试验中,604名超重或肥胖的成年人 (65-85岁) 被随机分配到MIND饮食或对照饮食中.
- 一个线性混合效应模型分析了全球认知分数的年度变化.
- 评估了参与者的特征,包括BMI,作为MIND饮食对认知影响的潜在修饰因素.
主要成果:
- 体重指数 (BMI) 是唯一发现的显著变量 (p=0.009).
- 在BMI≥35kg/m2 (n=213) 的个体中,MIND饮食组与对照组相比,MIND饮食组的认知分数显著更高 (0.040标准化单位/年,p=0.018).
- 在BMI<35 kg/m2的参与者中没有观察到显著的认知益处.
结论:
- MIND饮食对肥胖患者,特别是那些BMI为35公斤/平方米或更高的人有潜在的认知益处.
- 体重指数 (BMI) 是影响MIND饮食对老年人认知健康有效性的关键因素.
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