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低肝脏衍生的IGF-1驱动食物限制的雄性小鼠生长激素分泌的变化

Maria E de Sousa¹, Ligia M M Sousa¹, Edward O List²

¹Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo 05508000, Brazil.

|October 8, 2025

概括

慢性食物限制通过抑制肝脏衍生的胰岛素类生长因子-1 (IGF-1) 来改变生长激素 (GH) 分泌,从而将GH的释放从小鼠的脉动性转移到增强性模式.

科学领域:

内分泌学在内分泌学.
代谢调节代谢调节代谢调节
分子生物学分子生物学

背景情况:

慢性食物限制 (FR) 改变了生长激素 (GH) 的分泌,从脉动到强化模式.
这种GH分泌的转变背后的确切生理机制尚不清楚.

研究的目的:

调查由肝脏衍生的抑制胰岛素样生长因子-1 (IGF-1) 在调解FR小鼠观察到的改变GH分泌模式中的作用.
将肝细胞特异性GH受体 (GHR) 淘汰小鼠中的GH分泌模式与FR野生型 (WT) 小鼠的GH分泌模式进行比较.

主要方法:

在ad libitum养的肝细胞特异性GHR淘汰 (AlbuminΔGHR) 雄性小鼠中分析了GH分泌模式,并与ad libitum养和FR对照雄性小鼠进行了比较.
测量了血清IGF-1,肝脏Igf1信使RNA (mRNA),血格林和肝脏Ghr mRNA水平.
用肝细胞特异性腺相关病毒诱导的IGF-1表达来评估其对FR WT小鼠GH分泌的影响.

主要成果:

两个AlbuminΔGHR养和FR WT小鼠显示抑制血清IGF-1和肝脏Igf1mRNA.
与FR小鼠相似,食AlbuminΔGHR的小鼠表现出增加的总和基底GH分泌量,而GH脉冲幅度没有变化.
在FR WT小鼠中,肝细胞特异性IGF-1的恢复使GH分泌模式正常化,表明IGF-1的关键作用.

结论:

抑制肝脏衍生的IGF-1是推动FR雄性小鼠转向增强性GH分泌的主要机制.
这项研究阐明了一条关键的分子途径,该途径将营养状况,肝功能和GH调节联系起来.

关键词:

GH GH GH GH 的意思是什么?在IGF-1的基础上,IGF-1 在下丘脑中,下丘脑神经内分泌学神经内分泌学

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