功能工程Paliperidone纳米乳液的优化和评估,以改善通过鼻腔路线通过大脑输送
Niserga D Sawant1, Pratima A Tatke1, Namita D Desai1
1C. U. Shah College of Pharmacy, SNDT Women's University, Santacruz (W), Mumbai 400049, Maharashtra India.
Molecular pharmaceutics
|October 8, 2025
概括
这项研究开发了基托桑工程的paliperidone纳米乳液,用于鼻脑输送. 这些增强的纳米乳液显示出改善的生物相容性和有效性,在向大脑输送帕利佩里.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 神经科学是一个神经科学.
背景情况:
- 帕利佩里是一种BCSII类抗精神病药物,由于溶解度低,需要加强脑部输送策略.
- 鼻腔通道提供了一个直接的途径,用于进行非侵入性脑药物输送.
- 奇托桑的粘粘性和增强透性的特性使其适合用于鼻腔药物配方.
研究的目的:
- 开发和表征素功能化的帕利皮里纳米乳液,以增强鼻脑输送.
- 评估工程纳米乳液的粘粘度,透度和生物相容性.
- 在大鼠模型中评估纳米乳液在体内疗效.
主要方法:
- 使用自发乳化和超声波来制备的纳米乳液,通过Design-Expert软件进行优化.
- 通过FTIR,Ninhydrin试验和TEM证实了素功能化.
- 在体外释放药物,ex vivo透研究通过山羊鼻腔粘膜.
- 使用RPMI 2650和Neuro2A细胞系评估生物相容性;在Wistar大鼠中的体内研究.
主要成果:
- 优化的纳米乳液呈现出155±5.5nm的液滴大小和正的泽塔电位 (+40.5±3.5mV).
- 基托桑工程证实了成功地修改了表面.
- 实体研究显示,纳米乳液增强了帕利皮里的流量 (23.31 μg/cm2/h),与人工合成的 (17.87 μg/cm2/h) 相比.
- 工程化纳米乳液证明了生物相容性,并改善了体内效应 (触觉,记忆,焦虑解消).
结论:
- 松功能化的帕利皮里纳米乳液代表了有效的鼻脑输送的有希望的策略.
- 该配方增强了药物透,并表现出良好的生物相容性和体内疗效.
- 这种方法为治疗神经系统疾病提供了一种非侵入性和先进的方法.
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