长时间禁食以优化心肌中氧葡萄糖抑制
Fatima Abdullahi1, Khalid Makhdomi1, Jasmit Shah2,3
1Department of Radiology.
Nuclear medicine communications
|October 8, 2025
概括
18小时或更长时间的禁食有效地抑制了18F-FDG的生理心肌吸收,有助于诊断心脏炎症. 这种简单的协议是可复制和有价值的,特别是在资源有限的环境中.
科学领域:
- 核医学是一种核医学.
- 心脏病学 心脏病学
- 医学成像医学成像
背景情况:
- 18F-氧葡萄糖 (18F-FDG) PET对于诊断心脏炎症疾病至关重要.
- 18F-FDG的生理心肌吸收可能会干扰检测病理吸收.
- 抑制生理吸收对于准确评估心脏炎症是必要的.
研究的目的:
- 评估禁食时间在抑制心肌生理性18F-FDG吸收方面的有效性.
- 为评估心脏炎症建立一个实用的成像协议.
- 为了确定PET成像的最佳禁食期.
主要方法:
- 对450名接受全身18F-FDG PET/CT治疗的患者进行了回顾性审查.
- 患者被分为三个禁食组:<12h,12-17h和≥18h.
- 通过两个独立的读者对心肌FDG吸收的定性分级;使用Cohen's Kappa评估的读者间一致性.
主要成果:
- 充分的心肌抑制率为60% (<12h),66% (12-17h) 和77.3% (≥18h) (P=0.005).这些比例均为60%.
- 禁食持续时间≥18h显示明显更高的抑制率.
- 抑制与性别和BMI有关,但不是血糖,年龄或糖尿病. 互读者一致性非常好 (科恩的卡帕0.909).
结论:
- 禁食≥18小时对于抑制心肌生理性18F-FDG吸收是优越的.
- 这种延长的禁食协议增强了对心肌炎症的评估.
- 简单,可重复的视觉分级方法适合临床实践,特别是在资源有限的环境中.
相关概念视频
01:24Metabolic States of the Body: Fasting and Starvation
2.7K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.7K
01:18Metabolic States of the Body: The Postabsorptive State
1.2K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.2K