68的假阳性结果Ga-DOTATOC PET/CT:一个系统的审查
Dhuha Al-Adhami1, Ahmed Saad Abdlkadir1, Sze Ting Lee2
1King Hussein Cancer Center (KHCC), Clinic of Nuclear Medicine and PET/CT, Amman, Jordan.
Molecular imaging and radionuclide therapy
|October 8, 2025
概括
-68 DOTATOC扫描的假阳性结果很常见,特别是在腹部和头部/部. 了解这些陷可以改善诊断,并可能揭示这种成像剂的新用途.
科学领域:
- 核医学就是核医学.
- 放射性药物 放射性药物 放射性药物
- 诊断成像 诊断成像 诊断成像
背景情况:
- -68 DOTATOC (Ga-DOTATOC) 是广泛用于诊断神经内分泌瘤 (NETs).
- 假阳性结果可能导致误诊和不必要的干预.
- 需要对报告的假阳性结果进行系统审查,以提高诊断准确度.
研究的目的:
- 系统地审查和分类报告的Ga-DOTATOC的假阳性发现.
- 确定这些虚假阳性结果的常见部位和病因.
- 加强对Ga-DOTATOC.68的理解和临床应用.
主要方法:
- 在PubMed,Web of Science和Scopus数据库进行系统搜索,更新至2024年3月4日.
- 由三个作者根据包含/排除标准对标题和摘要进行独立选.
- 对42篇涉及601名患者的文章进行了定性分析.
主要成果:
- 总共有219个假阳性结果被识别和分类.
- 非瘤病因 (50.2%) 占主导地位,其次是良性 (27.4%) 和恶性瘤 (22.4%).
- 腹部 (30.6%) 和头部/部 (20.5%) 是错误阳性最常见的部位,通常与脑膜瘤和NET有关.
结论:
- 在Ga-DOTATOC成像中,错误的阳性结果是频繁且多样化的.
- 了解这些陷对于准确的诊断和患者管理至关重要.
- 识别假阳性可能会扩大Ga-DOTATOC的实用性,超越NET和脑膜瘤.
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