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预测因素和CAR-T细胞治疗相关心血管毒性基线风险分层

Dimitrios Farmakis¹, Konstantinos I Karampinos¹, Raul Cordoba²

¹Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece.

European journal of haematology

|October 8, 2025

概括

化学抗原受体 (CAR) -T细胞治疗可以导致心血管不良事件 (CVAE). 这项研究确定了七种CVAE预测因子,并开发了CART-7评分,用于接受CAR-T细胞治疗的患者的风险分层.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

化学抗原受体 (CAR) -T细胞疗法是一种新的血液恶性瘤治疗方法.
卡尔-T细胞疗法与心血管不良事件 (CVAE) 的显著风险有关.
基线心血管 (CV) 风险分层对于接受心毒性抗癌疗法的患者至关重要.

研究的目的:

为了确定与CAR-T细胞相关的CVAE的预测因子.
为CAR-T细胞相关的CVAE开发一个风险分层分数.

主要方法:

对12项涉及1354名患者的研究进行了元分析.
在有和没有CVAE的患者之间比较了基线临床,生物标志物,心声和药物数据.
重要预测因素的相对风险 (RR) 被用于构建风险评分.

主要成果:

在1354名患者中,有228名患者 (16.8%) 患有CVAE.
重要预测因素包括冠状动脉疾病,高脂血症,糖尿病,高血压,心房动,心力衰竭和吸烟.
开发了CART-7评分,范围为0-33分,风险类别为:低 (0-8),中等 (9-17),高 (18-25) 和非常高 (26-33).

结论:

七种基线心血管疾病与CAR-T细胞相关的CVAE显著相关.
在接受CAR-T细胞治疗的患者中,CART-7评分有助于基线CV风险分层.
建议对CART-7评分进行进一步验证,以便在临床实施.

关键词:

在CAR-T细胞中.癌症癌症癌症癌症癌症心脏有毒性心脏有毒性血液学的恶性瘤.这是一个元分析.风险分层的分层化

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