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在结肠直肠癌和瘤进展中对F11R的下调

Fengjiao Wang^1,2, Xiumin Bao^1,3,2, Qingchun Lei

¹Department of Gastroenterology, Affiliated Hospital of Kunming University of Science and Technology, the First People's Hospital of Yunnan Province, Kunming, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|October 8, 2025

概括

结直肠癌中F11R (结合粘附分子-A) 的减少表达与瘤进展和不良结果相关. F11R调节表皮质-介质细胞过渡和Rap1信号,表明其作为预后生物标志物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

结肠直肠癌 (CRC) 是一个重要的全球健康问题.
在CRC中F11R (结合粘附分子-A,JAM-A) 的预后价值和功能作用仍然不完全理解.
了解F11R在瘤进展和转移中的作用对于开发新的治疗策略至关重要.

研究的目的:

评估F11R在结直肠癌中的预后价值和表达特征.
阐明F11R在上皮层-介质细胞过渡 (EMT) 和Rap1信号传递中的功能作用.
确定F11R作为CRC的潜在预后生物标志物.

主要方法:

使用TCGA和HPA数据集进行综合生物信息分析.
免疫组织化学 (IHC) 和单细胞RNA测序用于蛋白质表达和定位.
在体外测试 (CCK-8,Transwell,scratch,流细胞计) 来评估CRC细胞的行为.
西部涂抹以评估EMT标记物和Rap1激活.

主要成果:

与正常组织相比,CRC组织中的F11R表达显著减少.
沉默F11R促进了CRC细胞的增殖,迁移,入侵和EMT,同时减少了亡.
F11R表达与特定的免疫细胞子集相关,并涉及T细胞受体信号传递和紧结路径.

结论:

在调节EMT和Rap1信号传输方面,F11R起着至关重要的作用,影响CRC转移.
减少F11R表达与CRC的不良结果和瘤进展有关.
F11R作为CRC的潜在预后生物标志物,具有特定的细胞类型丰富和免疫透链接.

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