部瘤:简化对低度发育不良的后续治疗
Aurore Carlo1, Laurent Siproudhis1, Amandine Landemaine1
1Department of Gastroenterology, CHU Rennes and University of Rennes, F-35,000 Rennes, France.
概括
患有低级状内皮病变 (LSIL) 的患者患有高级状内皮病变 (HSIL) 的风险较低. 然而,HPV16阳性和44岁以上的年龄增加HSIL风险,建议量身定制的查间隔.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 门癌症查依赖于在特定人群中重复评估.
- 低度病变是常见的,但进展到侵袭性癌症是罕见的.
- 识别风险因素对于优化查策略至关重要.
研究的目的:
- 为了确定患有低度内皮层病变 (LSILs) 的患者的风险水平.
- 根据风险分层,完善门癌查策略.
- 评估与进展到高度状内皮病变 (HSILs) 相关的因素.
主要方法:
- 从接受内皮质病变查的患者收集前性数据.
- 包括患有LSIL的患者,细胞学,病毒学和至少两项临床评估.
- 提取HPV DNA查,HSIL和侵袭性癌症发病率数据.
主要成果:
- 194名患有LSIL的患者被随访了平均48个月.
- 累计HSIL概率为1年后13.7%,5年后为44.4%.
- HPV16状态和年龄>44岁与增加HSIL风险有关;其他因素如艾滋病毒,HPV亚型 (16岁除外),吸烟和BMI无意义.
结论:
- 患有LSIL的患者通常患HSIL的风险较低,特别是那些HPV16阴性患者.
- 44岁以上的年龄和HPV16阳性是HSIL发展的关键风险因素.
- 在没有这些风险因素的LSIL患者中,在第一年后的4年查间隔可能是合理的.
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