在LNCRNAS,新陈代谢细胞死亡,以及在生殖器毛细菌恶性疾病中的免疫微环境中进行互换
V Gordiiuk1, L Shevchenko1, D Todoryshyn2
1Institute of Molecular Biology and Genetics, the NAS of Ukraine, Kyiv, Ukraine.
Experimental oncology
|October 8, 2025
概括
长非编码RNAs (lncRNAs) 调节细胞死亡的新型形式,如尿癌中的cuproptosis和ferroptosis. 这些lncRNAs影响瘤免疫力,并为精确瘤学提供潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症新陈代谢 癌症新陈代谢
背景情况:
- 生殖尿路癌症 (前列腺,膀,) 由于患病率和治疗耐药性而构成重大健康挑战.
- 代谢重编程在癌症中至关重要,影响生长,细胞死亡和瘤免疫微环境.
研究的目的:
- 审查长非编码RNAs (lncRNAs) 在调节阴囊,阴囊和阴囊癌中的作用.
- 探索 lncRNA 签名,代谢细胞死亡和瘤免疫微环境之间的联系.
- 评估 lncRNAs 作为预后生物标志物和免疫治疗反应预测者的潜力.
主要方法:
- 文献综述综合了有关lncRNAs,代谢细胞死亡和尿生殖系统恶性瘤的当前研究.
- 分析lncRNA参与调节cuproptosis,ferroptosis和disulfidptosis的情况.
- 检查lncRNA表达模式与瘤免疫微环境之间的关联.
主要成果:
- 特定的lncRNA签名参与调节生殖尿路癌的代谢细胞死亡途径 (cuproptosis,ferroptosis,disulfidptosis).
- lncRNA表达影响癌细胞的增殖,迁移和入侵.
- lncRNA模式与瘤免疫微环境特征和免疫治疗反应相关.
结论:
- lncRNAs在生殖尿路癌代谢和免疫中发挥着多方面的作用.
- lncRNAs是尿生殖系统癌症精密瘤学的有前途的治疗标.
- lncRNA表达特征可以作为预后和治疗分层的信息生物标志物.
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