血压的终身负担与中年认知功能有关
Wei Chen1, Changwei Li2, Ruiyuan Zhang1
1Department of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).
Hypertension (Dallas, Tex. : 1979)
|October 8, 2025
概括
在一生中累积暴露于高血压 (BP) 与中年低认知功能有关. 对于评估认知衰退和痴呆症的风险而言,一个生命过程的视角至关重要.
科学领域:
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 研究心血管风险因素对认知功能的长期影响.
- 使用纵向的博加卢萨心脏研究队列进行全面分析.
研究的目的:
- 检查心血管风险因素和中年认知功能的累积生命周期负担之间的关系.
- 评估长期暴露于血压等因素对认知轨迹的影响.
主要方法:
- 对912名参与者的分析,在中年测量认知功能.
- 从童年到成年时长度追踪身体质量指数,血压,动脉动脉指数和LDL胆固醇.
- 计算曲线下的总和增量面积 (AUC),以量化长期风险因素负担和趋势.
主要成果:
- 中年期的认知功能与总和渐进的缩血压AUC相反相关.
- 较高的累积缩血压负担与较低的认知评分有关,独立于共变量.
- 关联在不同种族和性别群体中保持一致.
结论:
- 在一生中累积暴露于高血压会对大脑健康产生负面影响.
- 一个终身方法为评估与认知衰退和痴呆症相关的风险提供了一个卓越的框架.
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