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网络应用程序为COVID-19患者指导双模体嗅觉训练:一个随机试验

C Vandersteen¹, M Payne², C Becker³

¹Institut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, UR2CA-REBOOT, Universite Cote d'Azur, Nice, Alpes- Maritimes, France;Universit Cote d'Azur, laboratoire CoBTeK, Nice, Alpes-Maritimes, France.

|October 8, 2025

概括

使用MaMadeleine套件进行视觉嗅觉训练,改善了后急性COVID-19综合征 (PACS) 患者的嗅觉功能和生活质量. 多模式培训也提高了患者对该计划的坚持.

科学领域:

神经学神经学
耳鼻喉科耳鼻喉科耳鼻喉科
康复医学康复医学康复医学

背景情况:

持续的嗅觉功能障碍 (dysosmia) 影响了许多后急性COVID-19综合征 (PACS) 患者感染后很长时间.
认知功能,包括语义记忆,可能会被损害在PACS患者未解决的嗅觉问题.
视觉嗅觉双模训练提供了一种潜在的方法来刺激受影响的嗅觉和认知区域.

研究的目的:

评估马马德琳视觉嗅觉训练套件在改善PACS患者的嗅觉功能的有效性.
评估双模嗅觉训练对嗅觉恢复和生活质量的影响.
通过使用网络应用程序辅助的培训程序来调查治疗坚持.

主要方法:

一项前性随机研究涉及83名PACS患者 (年龄大于=14) 患有感染后嗅觉功能障碍.
参与者经历了两个月的简单 (A) 或语义 (B) 视觉嗅觉训练,使用MaMadeleine套件.
评估包括临床评估,嗅探棒测试,生活质量问卷和通过网络应用程序监测遵守.

主要成果:

在79.4% (正鼻) 和58.9% (逆鼻) 的患者中,Madeleine培训导致了主观的嗅觉改善.
嗅探棒测试成绩有所改善,帕洛斯米亚和幻影症均下降了20%.
在两组培训中,生活质量显著改善,在语义培训组 (B) 中观察到更好的坚持.

结论:

麦当劳的培训计划有效地改善了PACS患者的主观嗅觉功能,客观测试结果和生活质量.
多模式训练方法似乎可以提高患者对嗅觉康复的坚持.
对于具有特定语义记忆障碍的PACS患者,建议对其进行进一步研究.

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