功能性近红外光谱作为稳定精神分裂症的诊断辅助
Suzhen Zhang1,2, Ting Li3, Liangliang Chen3
1Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in psychiatry
|October 8, 2025
概括
功能近红外光谱学 (fNIRS) 在评估精神分裂症 (SCZ) 的认知缺陷方面表现有前途. 在口头流利测试 (VFT) 期间的大脑激活模式可以帮助区分SCZ患者与健康个体.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 生物医学工程 生物医学工程
背景情况:
- 认知障碍是精神分裂症 (SCZ) 的核心特征,严重影响患者的功能.
- 与SCZ相关的认知缺陷的潜在神经机制仍然不完全理解.
- 需要可靠的神经成像工具来对SCZ进行客观认知评估.
研究的目的:
- 通过功能近红外光谱学 (fNIRS) 在口语流性测试 (VFT) 中测量的大脑激活模式与SCZ认知缺陷之间的关联.
- 评估fNIRS在确定稳定的SCZ患者中的诊断潜力.
主要方法:
- 45名稳定的SCZ患者和30名健康对照 (HC) 在VFT期间接受了fNIRS监测.
- 评估了人口统计数据,症状严重程度 (PANSS) 和认知功能 (MCCB).
- 使用fNIRS分析了前皮质中的血液动力学反应.
主要成果:
- 在VFT期间,SCZ患者在前腔区域表现出言语流性降低和血液动力学反应改变 (较低的β值和积分值 (IV)) .
- 叶的IV和48通道的β值显示了SCZ的诊断灵敏度 (AUC分别为0.781和0.762).
- 叶IV与多个认知领域正相关,而通道48β值与处理速度相关.
结论:
- fNIRS显示出作为SCZ认知评估的临床工具的潜力.
- 叶的积分值和48通道的β值可以作为区分SCZ的候选生物标志物.
- 这些发现支持使用fNIRS来理解和潜在地诊断精神分裂症的认知障碍.
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