心肌活性菌株能量密度和收缩率:左心室功能和心血管风险的新型预后工具
David H MacIver1,2, Henggui Zhang1, David Oxborough3
1Biological Physics Group, Department of Astronomy and Physics, University of Manchester, Manchester M13 9PL, UK.
心肌活性应变能量密度 (MASED) 与传统指标相比,可以更好地评估心脏功能和心血管风险. 这种新型测量,特别是全球纵向活性菌株能量密度 (GLASED),显示出对死亡率的强大预测价值.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 心脏机械学 心脏机械学
背景情况:
- 心肌活性应变能量密度 (MASED) 是心脏收缩功能的新型测量方法.
- MASED使用工程科学的原则来量化心肌工作.
- 它代表了用于工作的每单位心肌体体积的能量.
研究的目的:
- 评估MASED的预测值,特别是全球纵向活性应变能量密度 (GLASED),用于死亡率.
- 为了将GLASED与常规的心脏功能指标比较,例如喷射率和全球纵向应变.
- 探索回声心脏学GLASED与健康个体的人口因素的关联.
主要方法:
- 心血管磁共振成像 (CMR) 被用于评估GLASED.
- 分析包括患有高血压心脏病,扩大心肌病和粉样性心脏病 (n=183) 的患者.
- 为了评估GLASED的预后能力,使用了大量的社区队列 (n=44,957).
主要成果:
- 在心脏病患者中,GLASED在死亡率方面的预测价值比射出分数和全球纵向应变更高.
- 在一个大队列中,GLASED是所有原因死亡率和主要心血管不良事件的最强独立预测因素.
- 在健康个体中,心声学玻璃显示了与年龄和性别的显著关联.
结论:
- MASED,特别是GLASED,提供了更准确,更有机理基础的对左心室功能的评估.
- 玻璃提供了增强的心血管风险分层和潜在的指导心力衰竭管理.
- 需要进一步的预后研究来验证MASED在不同人群中的临床效用.
更多相关视频
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
12:12Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
相关概念视频
Pathophysiology of Cardiac Performance
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
