全谷物减轻了中国食道状细胞癌幸存者的免疫介导炎症:一个多中心问卷研究
Ya-Qiong Ren1, Yuxiang Wang2, Yang Li3
1Department of Radiotherapy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in immunology
|October 8, 2025
概括
在食道癌症幸存者中,较高的全谷物摄入量与减少全身炎症有关. 每天消费大约50g,多种多样,支持饮食建议,以获得更好的健康结果.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 食道状细胞癌 (ESCC) 幸存者经常经历全身炎症.
- 饮食因素可能会影响癌症幸存者的炎症焦虑.
- 了解饮食等可修改的生活方式因素对于幸存者护理至关重要.
研究的目的:
- 调查习惯性全谷物消费与患者报告的全身炎症应急症之间的关联.
- 为了确定是否增加全谷物摄入量与ESCC幸存者的较低炎症水平相关.
- 为ESCC存活率的饮食干预提供证据.
主要方法:
- 在山西省对392名成年ESCC幸存者 (I-IIIA阶段) 进行横截面问卷研究.
- 全谷物摄入量通过食物频率调查问卷进行评估,以每日克,密度和多样性为模型.
- 系统性炎症应激使用炎症应激指数 (IDI) 测量.
- 统计分析包括多变量逻辑和通用线性模型,用于剂量反应评估的限制立方线.
主要成果:
- 平均全谷物摄入量为35.4g/天;28.1%的参与者有较高的IDI.
- 全谷物摄入量较高的四分位数显示,IDI患病率升高显著下降 (p趋势<0.001).
- 全谷物摄入量每增加10g/天都会使平均IDI (MR 0.94) 减少6%.
- 观察到剂量与反应的关系,益处停滞在每天60克左右.
结论:
- 较高的全谷物摄入量,特别是每天大约50克和更多的品种,与ESCC幸存者的系统性炎症应急症显著降低有关.
- 研究结果支持将以谷物为中心的饮食咨询整合到食道癌患者的生存护理中.
- 通过增加全谷物消费来改变饮食可能是一个可行的策略来管理这一群体的炎症.
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