极度早产婴儿的生存率和短期疾病:一项前性队列研究
Shikha Khandelwal1, Vikram Datta2
1Neonatology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, IND.
Cureus
|October 8, 2025
概括
印度极早产婴儿的生存率为61.4%,高于其他低收入和中等收入国家,但低于高收入国家. 较高的出生体重和五分钟的Apgar分数预测了这些婴儿的更好的结果.
科学领域:
- 新生儿科学 新生儿科学
- 周围生理学 周围生理学
- 公共卫生 公共卫生
背景情况:
- 在低收入和中等收入国家 (LMIC) 的极度早产 (EPT) 婴儿的结果是可变的.
- 对于印度的EPT婴儿,存在有限的妊娠年龄 (GA) 具体数据.
研究的目的:
- 评估EPT婴儿的存活率和短期发病率,出生时 ≤28周怀孕.
- 在北印度三级NICU内确定这个脆弱人群中死亡率的预测因素.
主要方法:
- 一项前性观察队列研究包括83名婴儿出生 ≤28周怀孕.
- 收集了有关母亲,围产和新生儿因素的数据.
- 多变量逻辑回归分析死亡率预测因素.
主要成果:
- 到出院的总体存活率为61.4%,随着妊娠年龄的增加而增加.
- 导致死亡的主要原因包括败血症和极端早产.
- 较高的出生体重和5分钟的阿帕尔分数是生存的独立预测指标 (AUC 0.89).
结论:
- 这个印度群体的生存率超过了LMIC平均水平,但落后于高收入国家基准.
- 出生体重和5分钟的阿普加尔评分是关键的预后指标.
- 改善围产期护理,感染控制和新生儿实践对于更好的结果至关重要.
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