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上腺功能缺陷检查点:优化免疫检查点抑制剂治疗中的查

Hima Darapu¹, Navya Konindala², Ravi Paluri³

¹Endocrinology, Internal Medicine, Wake Forest University School of Medicine, Winston Salem, USA.

|October 8, 2025

概括

免疫检查点抑制剂治疗很少包括上腺功能不足查,导致诊断不足. 通过标准化生化测试进行早期检测对于接受伊皮利木巴-尼沃木巴的患者至关重要,以防止严重的结果.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

从其他毒性中区分免疫检查点抑制剂 (ICI) 诱导的内分泌异常是具有挑战性的.
生物化学监测对于患有疲劳和虚弱的患者至关重要.
目前对上腺功能衰竭 (AI) 查的指导方针各不相同,遵守是不确定的.

研究的目的:

评估在接受伊皮利姆巴-尼沃姆巴的患者中AI查实践.
在这个人群中确定AI的发病率.
识别早期AI检测中的差距.

主要方法:

一个回顾性队列研究,对185名接受伊皮利姆巴-尼沃姆巴治疗的成年患者进行了研究.
从电子健康记录中提取数据,包括人口统计数据,癌症细节,ICI疗法和实验室值 (皮质醇,ACTH,TSH).
评估AI和甲状腺功能障碍的查率,并分析AI诊断时间和设置.

主要成果:

只有一个患者接受了全面的基线和间隔ACTH和皮质醇测试.
甲状腺刺激激素 (TSH) 被持续监测.
二次性AI在9.1%的患者中被诊断出,通常是在急性护理机构出现症状后.

结论:

由于ICI诱导的上腺功能不全是次要的,但在Ipilimumab-nivolumab治疗中没有得到充分的认可.
对AI的查很少进行,与甲状腺功能监测不同.
对于基线和定期ACTH和皮质醇测试的标准化协议是早期检测和干预所需的.

关键词:

上腺功能不全 (ai)检查点抑制剂治疗检查点抑制剂治疗这是一种CTLA-4抑制剂.内分泌系统的 IRE 是什么?免疫检查点抑制剂 (icis) 的使用.免疫检查点抑制剂诱导的内分泌病变.与免疫相关的不良事件 (IRAE)这里是 ipilimumab 的所在地.与ipilimumab相关的不良事件

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