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阿斯特拉加洛西德IV通过调节ITGB1/PTK2/p38路径来缓解系统性红斑狼:综合网络药理学和实验验证

Zhongfu Tang¹, Lili Cheng¹, Ming Li¹

¹Department of Rheumatology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, People's Republic of China.

Drug design, development and therapy

|October 8, 2025

概括

阿斯特拉加洛酸IV (AS-IV) 通过减少脏损伤和抑制炎症性免疫反应,有效治疗狼. 这种天然化合物调节关键的分子通路,为系统性红斑狼 (SLE) 提供治疗潜力.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種醫學.

背景情况:

系统性红斑狼 (SLE) 是一种自身免疫性疾病,其特征是免疫细胞功能障碍和器官损伤.
阿斯特拉加索酸IV (AS-IV) 是从Astragalus membranaceus中提取的,具有抗炎和免疫调节的特性.

研究的目的:

评估AS-IV对SLE的治疗潜力.
阐明AS-IV在治疗SLE的潜在机制.

主要方法:

MRL/lpr小鼠接受了不同剂量的AS-IV或普雷迪松 (Pred) 治疗,C57BL/6小鼠作为对照.
评估了病理,免疫参数 (细胞因子,抗体,补充物) 和分子标,使用基因病理学,ELISA,流细胞计,网络药理学和分子对接.
研究了ITGB1/PTK2/p38信号轴在AS-IV的作用机制中的作用.

主要成果:

通过减少病变,免疫复合体沉积和炎症性细胞因子,AS-IV显著改善了狼性炎.
用AS-IV正常化免疫标记物进行全身治疗,包括抗dsDNA抗体和补充剂水平,与普德尼松相当.
在AS-IV下调的促炎途径 (ITGB1,PTK2,p38,Th1/Th2/Th17) 和上调的调节T细胞 (Tregs).

结论:

AS-IV在改善SLE进展方面显示出显著的治疗价值.
该机制涉及调节ITGB1/PTK2/p38轴以抑制免疫炎症反应.
AS-IV作为系统性红斑狼的潜在治疗方法具有前景.

关键词:

阿斯特拉加洛西德IV 免疫功能免疫功能免疫功能炎症因素是炎症因素.网络药理学网络药理学系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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