与上腺瘤相关的男性模式雄激素性脱发:一个案例报告
Maria Fernanda Figueroa Hernández1, Marysol Macedo Perez1, María Teresa Alonso de León1
1Dermatology Department, Hospital General "Dr. Manuel Gea González", Mexico City, Mexico.
Skin appendage disorders
|October 8, 2025
概括
这一案例突出了一个罕见的男性模式发的例子,在绝经后的女性中是由双边上腺腺瘤引起的. 手术切除瘤使丸激素水平正常化,并消除了高雄性质症的症状.
科学领域:
- 内分泌学 在内分泌学.
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 雄激素性脱发症 (AGA) 通常呈现为男性或女性模式脱发.
- 在女性中,AGA可以表明潜在的高雄性质,尽管很少见 (0.2%的病例).
- 诸如先天性上腺增生症或卵巢/上腺瘤之类的疾病可能导致过高雄性质.
研究的目的:
- 报告一名绝经后妇女因双边上腺腺瘤而患有男性模式脱发症的病例.
- 强调研究更年期后妇女有男性化症状的高雄性质的重要性.
- 讨论雄激素产生瘤的诊断和治疗方法.
主要方法:
- 一个62岁的女性呈现了十年的脱发和发症.
- 医疗检查包括评估 hirsutism,男性发型脱发 (汉密尔顿七年级),和三眼镜.
- 进行了实验室测试 (总) 和成像 (腹部CT扫描).
主要成果:
- 这位患者表现出面部,腹部和胸部的头发发发,同时也出现了前面 - 面 - 头头发的脱发.
- 三镜检查显示了雄性发育性白发症的迹象:毛囊口的损失,单个毛囊单元,缩小的毛发和周围毛囊棕色光环.
- 检测到总的升高 (10.15 ng/mL) 和双边上腺腺瘤.
- 进行了腹腔镜激进上腺切除术,导致的正常化和症状的改善.
结论:
- 绝经后妇女的新发性高雄性质症可能会导致像男性模式脱发症这样的男性化症状.
- 超过5nmol/L的水平需要对产生雄激素的瘤进行检查.
- 手术切除产生雄激素的瘤是绝经后妇女的首要治疗方法,这些妇女有男性化症状和雄激素过量.
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