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使用矩阵匹配的纳米颗粒压缩粉颗粒对生物碳酸盐样品进行定量映射的LA-ICP-TOF-MS
Ana Lores-Padin1, Thibaut Van Acker1, Niels J de Winter2
1Atomic & Mass Spectrometry-A&MS Research Group, Department of Chemistry, Ghent University, Campus Sterre Krijgslaan 281-S12 9000 Ghent Belgium ana.lorespadin@ugent.be.
Journal of analytical atomic spectrometry
|October 8, 2025
概括
商业上可用的纳米颗粒压制颗粒可以提高生物碳酸盐的元素测绘精度. 然而,颗粒的均性对于使用激光除-诱导合等离子体-飞行时间-质谱法 (LA-ICP-TOF-MS) 的可靠量化至关重要.
科学领域:
- 地质化学 地质化学
- 分析化学 分析化学
- 生物地质化学生物地质化学
背景情况:
- 生物碳酸盐的定量元素测绘对于理解生物积累和环境记录至关重要.
- 激光切除-诱导合等离子体-飞行时间-质谱法 (LA-ICP-TOF-MS) 是一种强大的元素分析技术.
- LA-ICP-TOF-MS的准确性在很大程度上依赖于适当的校准参考材料.
研究的目的:
- 评估基于CaCO3矩阵的商用纳米颗粒压颗粒的微同质性.
- 评估这些颗粒对于使用LA-ICP-TOF-MS进行生物碳酸盐的定量元素测绘的有用性.
- 为了比较使用纳米颗粒对矩阵匹配校准与使用酸盐玻璃参考材料对非矩阵匹配校准的分析性能.
主要方法:
- 评估七种不同的商用纳米颗粒压颗粒.
- 使用LA-ICP-TOF-MS进行量化元素映射,激光束大小为20 × 20 μm2.
- 矩阵匹配校准 (纳米颗粒) 与非矩阵匹配校准 (NIST SRM 610酸玻璃) 的比较.
主要成果:
- 使用纳米颗粒和Ca作为内部标准的矩阵匹配校准显著提高了量化准确性 (大多数元素的80-120%回收).
- 一些纳米颗粒 (BPLM-NP,BAM-RS3-NP) 显示出更高的异质性,导致偏差的恢复.
- 观察到质量分数和相对标准偏差 (RSD) 之间的反相关性,突出显示了颗粒均性的重要性.
结论:
- 商用纳米颗粒压颗粒可以通过LA-ICP-TOF-MS提高生物碳酸盐的定量元素映射,当使用矩阵匹配校准时.
- 颗粒微同质性对于准确量化至关重要;异质颗粒可以引入重大偏差.
- 开发的LA-ICP-TOF-MS方法提供了高分辨率的多元素2D地图,使生物原始档案中元素分布的详细分析和跟踪生物积累成为可能.
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