在健康检查中MAFLD和CVD之间的关系中国人口:一个前性队列研究
Yao Dou1, Jiawei Cui1, Qi Gu2
1Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, China.
Therapeutic advances in chronic disease
|October 8, 2025
概括
与代谢相关的脂肪肝疾病 (MAFLD) 显著增加心血管疾病 (CVD) 的风险,特别是在代谢功能障碍超重/肥胖子组中. 按代谢健康和体重分层MAFLD患者有助于预测和预防心血管疾病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心血管疾病 (CVD) 是代谢相关脂肪肝疾病 (MAFLD) 患者死亡的主要原因.
- 了解MAFLD亚组中的心血管疾病风险对于有效的患者管理至关重要.
研究的目的:
- 调查不同代谢相关脂肪肝疾病 (MAFLD) 亚组中的心血管疾病 (CVD) 风险.
- 评估代谢状态和体重指数对MAFLD患者心血管疾病风险的影响.
主要方法:
- 从2017年6月到2023年1月的参与者数据的回顾性分析.
- 将MAFLD患者分为四个子组:代谢健康瘦/正常体重 (MHL),代谢健康超重/肥胖 (MHO),代谢功能障碍瘦/正常体重 (MDL) 和代谢功能障碍超重/肥胖 (MDO).
- 动脉样硬化心血管疾病风险评估使用中国成年人标准化流程图,并对混因素进行调整.
主要成果:
- 在MHL,MHO,MDL和MDO的比例分别为0.77%,10.05%,1.29%和16.86%.
- 经过调整后,MAFLD仍然是高心血管不良事件 (HACE) 的独立风险因素.
- 与MHL亚组相比,MDL亚组表现出最高的心血管疾病风险,其次是MDO亚组,与MHL亚组相比 (p <0.05). 在MHO和MHL之间没有发现显著差异.
结论:
- 与代谢相关的脂肪肝疾病 (MAFLD) 与心血管疾病 (CVD) 的风险增加有显著的关联,特别是在代谢功能障碍超重/肥胖 (MDO) 组中.
- 根据体重指数和代谢功能障碍对MAFLD患者进行分层是准确的心血管风险分层和预防策略的关键.
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