克罗恩病的静脉静脉维护:一个单中心的回顾性队列研究
Yuting Wang1, Shiyuan Lu1, Wen Hu2
1Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Therapeutic advances in gastroenterology
|October 8, 2025
概括
在克罗恩病患者中,静脉输入的乌斯特基努马布维持疗法实现了高水平的无类固醇缓解和内镜愈合. 这种方法证明了可管理的安全概况,提供了可行的治疗选择.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在克罗恩氏病 (CD) 实践中,乌斯特基努马布 (UST) 的使用显示出低于最佳的持续性和有限的内镜愈合.
- 目前的治疗优化策略面临着耐用性和患者需求增加的挑战.
研究的目的:
- 评估静脉注射 (IV) ustekinumab 维护治疗克罗恩病的临床效用和安全性.
- 评估长期结果和患者对IV-UST维护的反应.
主要方法:
- 一个单一中心的回顾性队列研究包括234名接受2次IV-UST维持输液的CD患者.
- 使用基于体重的诱导等效剂量 (260-520毫克) 在响应指导的间隔内.
- 主要终点是24周的无皮质类固醇临床缓解.
主要成果:
- 在24周,88.1%的患者实现了无类固醇缓解,其中90.0%的患者显示C-反应蛋白正常化.
- 在52周内镜缓解率为48.7%.
- 内镜非缓解的预测因素包括基线CRP>5 mg/L,强度剂量和疾病持续时间≥1年. 不良事件发生率为44.4%,严重不良事件为3.0%.
结论:
- 静脉输入的乌斯特基努马布维持疗法有效地实现了在CD中高率的无皮质类固醇临床缓解.
- 该疗法显示出显著的内镜治疗潜力,具有可管理的安全性.
- 这种方案为优化克罗恩病管理提供了有价值的选择.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
488
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
488
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
490
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
490
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
434
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
434
Inflammatory Bowel Disease IV: Pharmacological Management
517
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
517
Drugs for Treatment of Ulcerative Colitis in IBD
456
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
456
Inflammatory Bowel Disease II: Crohn's Disease
952
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
952


